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Yi-An Chen
Computational Scientist

I am a postdoctoral fellow in the laboratory of Floris Barthel at The Translational Genomics Research Institute. I did my previous postdoc in the Lab of Chia-Lin Wei at The Jackson Laboratory where I studied 3D Genomic in Cancers. During these years, I have learned various NGS technologies.

My current research project is defining the regulatory landscape of functional and dysfunctional telomeric chromatin interactions. This project will use Telomere-C to address how telomere interaction shapes transcription.

In addition to science, I’m interested in music (from classic to modern), Karate, Pingpong, and DIY car maintenance.

Papers

Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization Mbegbu et al. 2026. bioRxiv.

KaryoScope: rapid, alignment-free sequence annotation for the pangenome era Ranallo-Benavidez et al. 2026. bioRxiv.

Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance Chen et al. 2025. bioRxiv.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

News

Lab at EMBO Telomere meeting

Four new manuscripts from the lab

Lab at ASHG 2025

Let's go Diamondbacks!

CSHL telomere meeting

One year anniversary lab lunch

Lab photos

Lab Dinner at Pemberton