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rranallo-benavidezobfuscate@tgen.org
T. Rhyker Ranallo-Benavidez
Computational Scientist II

As a computational scientist in the Floris Barthel lab at the Translational Genomics Research Institute, I am investigating how telomere dysfunction contributes to the formation of structural variants in glioblastoma. Previously, I was a postdoctoral fellow at the University of North Carolina at Charlotte where I developed bioinformatics pipelines to detect structural variants from long read sequencing data in Drosophila populations.

My research interests include algorithm development and optimization, reproducibility, long read sequencing analysis, and structural variant detection.

In my free time I enjoy playing Pokemon Go with my husband and daughter.

Papers

Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization Mbegbu et al. 2026. bioRxiv.

KaryoScope: rapid, alignment-free sequence annotation for the pangenome era Ranallo-Benavidez et al. 2026. bioRxiv.

A complete human pancreatic cancer genome Wagner et al. 2026. bioRxiv.

Haplotype-resolved genome assemblies of BJ and IMR-90 human fibroblast cell lines reveal extensive structural variation and enable reanalysis of historical sequencing data Ranallo-Benavidez et al. 2026. NAR.

Chromosome-arm-specific telomere length governs dual modes of structural genome evolution in IDH-mutant astrocytoma Jehangir et al. 2026. bioRxiv.

Hierarchical genomic feature annotation with variable-length queries Alanko et al. 2026. bioRxiv.

Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic Park et al. 2025. Nature Biotechnology.

Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance Chen et al. 2025. bioRxiv.

News

Rhyker presenting at RECOMB-Seq

Four new manuscripts from the lab

Lab at ASHG 2025

Let's go Diamondbacks!